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Methotrexate

Hi,
I was diagnosed with Lupus 6 months ago. I am on hydrozychloroquine and have now stopped prednisone.
2 months ago I started methotrexate (tablet once a week).
I have headaches (and migraines) and fatigue still and am wondering if those symptoms go after you've been on methotrexate for 3 months or if they continue forever?

  1. Unfortunately, I don't think there is any definitive answer to your question. Each and every person living with lupus is different, and will have a different response to medications like Methotrexate. I would reach out to your doctor who prescribed the medication if you are wondering what to expect in the long-term. Since your doctor is familiar with your full medical history and current medications, they should be able to answer your question about what symptoms you can expect to improve, and which symptoms may continue to linger.

    Wishing you well, - Cody (Lupus. net Team Member)

    1. Cody, thanks. It is very depressing isn't it? I see my Dr again in just under 2 months.

      1. , Let us know how it goes! Hope your headaches have eased before then!
        Gabby (team member)

    2. Actually it's the fatigue that is most upsetting. I have the MTX on monday, Folic acid on Tuesday and wednesday fatigue is so bad I have to stay in bed. Can't even read, sew, crochet or watch tv. Then thursday I'm still really tired but can read or sew or do something sitting down. Fine again by friday.

      1. , The fatigue is so hard to escape or explain to someone who isn't living with it everyday. We hear you. Sending hugs
        Gabby (team member)

    3. I’m so sorry that you are struggling. Are you seeing a neurologist for your headaches? If you haven’t, I strongly suggest it. I have severe migraines, even hemiplegic migraines that present like I’m having a stroke. It’s taken a long time but we’ve finally found the right concoction of meds that is working. I also get Botox for my migraines and it’s been a game changer. There are also some new meds available that work really well for many people. If you do see a neuro then please disregard this suggestion. Haha.

      Amber (lupus.net team moderator)

      1. I only usually get a migraine once a year and treat them with Rizatriptan. A miracle cure for me.
        It the methotrexate that have caused them to return.
        After a horror weekend I emailed my rheumatologist this morning and told he I can't keep having the medication for another 6 weeks before I see him. Hopefully he'll get back to me tomorrow.

      2. , Sorry you've been dealing with barriers to getting your medication! Have you heard back from your doctor yet? Sending hugs!
        Gabby (team member)

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