Hi I have had SLE since I was 17yrs old. I am now 67 and a year ago started having severe hives. After having allergy skin tests coming back negative I was sent to a hematologist/oncologist and had bloodwork done, which showed a high Tryptase level. I had a bone marrow biopsy done and it determined no cancer. I was told I have Cutaneous Mastocytosis which is an excess of mast cells in the skin probably related to my SLE. Has anyone experienced these hives and can share their experiences and treatment? I was told to use over-the-counter antihistamines which do not give me any relief from the hives. The hives usually show up after a night's sleep and get better during the day only to appear again the next morning. My lupus is under control so I am looking for any advice from anyone experiencing a similar diagnosis. Thank you in advance for any info anyone can share.