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DHEA (dehydroepiandrosterone)

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By Editorial Team

2 min read

Reviewed by: HU Medical Review Board | Last reviewed: August 2024 | Last updated: August 2024

Dehydroepiandrosterone (DHEA) is a hormone (steroid) produced by the adrenal glands that may help with some of the mild to moderate symptoms of lupus. It has not been approved by the US Food and Drug Administration for the treatment of lupus. It is used to treat hair loss, joint pain, fatigue, and brain fog.1-3

What are the ingredients in DHEA?

DHEA is a hormone that occurs naturally in the human body and is made by the adrenal gland. The body turns DHEA into other male and female hormones within the body. The man-made form is created using chemicals found in soy and wild yam.1-3

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How does DHEA work?

Scientists believe that DHEA works in people with mild to moderate lupus by increasing the level of DHEA in the blood. This is thought to boost the immune system and lower inflammation. But the use of DHEA is controversial, with some doctors questioning its long-term safety, especially in people with high cholesterol.2

Some studies have shown that DHEA helps improve symptoms of lupus, while other studies show it does not.1-3

DHEA can be purchased over-the-counter as a dietary supplement, but it is important to only take DHEA if your doctor prescribes it. Over-the-counter DHEA is not regulated, so you may not get an accurate or consistent dose. If your doctor wants you to take DHEA, you will need to get pills made at a compounding pharmacy.1,3

What are the possible side effects?

The possible side effects of DHEA include:1-3

  • Acne
  • Facial hair growth
  • Oily skin,
  • Sweating more than normal
  • Lowered production of HDLs ("good cholesterol") in women
  • Increased estrogen levels in postmenopausal women

These are not all the possible side effects of DHEA. Talk to your doctor about what to expect when taking DHEA. You also should call your doctor if you have any changes that concern you when taking DHEA.

Other things to know

Men with lupus should not take DHEA.1-3

People who are pregnant, may become pregnant, or are breastfeeding should not take DHEA.1-3

Do not take DHEA if you have cancer influenced by hormones or have a family history of those types of cancer.1-3

Before beginning treatment for lupus, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

Treatment results and side effects can vary from person to person. This treatment information is not meant to replace professional medical advice. Talk to your doctor about what to expect before starting and while taking any treatment.